SS-31 (ELAMIPRETIDE) (10MG)

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SS-31 (Elamipretide) Peptide

Overview

SS-31, also known as Elamipretide, MTP-131 or Bendavia, is a synthetic mitochondrial-targeting tetrapeptide developed to investigate mitochondrial function and cellular energy production. Unlike many research peptides that interact with cell surface receptors, SS-31 selectively accumulates in the inner mitochondrial membrane, where it binds to cardiolipin, a phospholipid essential for maintaining normal mitochondrial structure and function. ⁽¹⁾

This 10 mg research-grade lyophilized SS-31 is manufactured for laboratory studies involving mitochondrial biology, oxidative stress, cellular energy metabolism, and age-related cellular dysfunction.

Origin

SS-31 was developed by researchers Dr. Hazel Szeto and Dr. Peter Schiller as part of the Szeto-Schiller (SS) family of mitochondria-targeting peptides. The peptide was specifically engineered to rapidly enter cells and localize to mitochondria without being dependent on membrane potential, making it a unique tool for mitochondrial research. ⁽²⁾

Mechanism of action

SS-31 is designed to selectively bind cardiolipin in the inner mitochondrial membrane. Research suggests that this interaction may help stabilize mitochondrial structure, improve electron transport chain efficiency, reduce reactive oxygen species (ROS), and support ATP production during cellular stress. These properties have made SS-31 one of the most extensively studied mitochondrial-targeting peptides in preclinical research. ⁽¹⁾

Chemical Composition

Molecular formula: C ₃₂ H ₄₉ N ₉ O ₅

Molecular weight: 639.80 g/mol

Other Known Names: Elamipretide, MTP-131, Bendavia

Research and Clinical Studies

Research areas

Current laboratory studies are exploring SS-31 in models involving:

1. Mitochondrial dysfunction
2. Cellular energy metabolism
3. ATP production
4. Oxidative stress
5. Research into healthy aging
6. Skeletal muscle biology
7. Cardiovascular research
8. Kidney biology
9. Neuroprotection
10. Exercise physiology and recovery

Properties

1. 10 mg lyophilized SS-31 (Elamipretide)
2. High purity synthetic tetrapeptide
3. Mitochondria-targeted research connection
4. Stable freeze-dried formulation
5. Suitable for laboratory and analytical applications
6. Batch tested for identity and purity

Potential Research Benefits

Scientific studies have explored SS-31 for its potential role in:

1. Supporting mitochondrial integrity
2. Improving mitochondrial energy production
3. Reduction of oxidative stress in cellular models
4. Improving the efficiency of ATP synthesis
5. Protection of cells during metabolic stress
6. Supporting research into healthy cellular ageing
7. Examination of muscle and tissue resistance
8. Study of mitochondrial-related disorders

Observed effects vary depending on the experimental model and should not be interpreted as established clinical results. SS-31 remains an investigational compound under continued scientific evaluation. ⁽¹⁾

Storage

Store the lyophilized peptide refrigerated or frozen according to laboratory guidelines. After reconstitution, handle and store the material according to the manufacturer’s recommendations to maintain stability and research integrity.

SS-31 (Elamipretide) peptide is available for research and laboratory purposes only. Please review and comply with our Terms and Conditions before ordering.

References

1. National Center for Biotechnology Information. PMC9192202. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC9192202/
2. The Peptide Catalogue. SS-31 (Elamipretide) Research Guide. Available from: https://thepeptidecatalog.com/articles/ss-31-elamipretide-research-guide